These data suggest that miR-17-92 miRNA-mediated suppression of TGF-β signaling through Tgfbr2 downregulation is particularly important during early stages of skeletal development and that the TGF-β signaling upregulation is responsible for skeletal defects in Feingold syndrome type 2. The gene discussed is TGFB1; the disease is Feingold syndrome type 2.