These two key Env-CD4 signals for HIV-1 fusion, entry, and infection have been a central issue in the present study, where we observed that primary Envs from viruses of the LTNP-EC cluster individuals present nonefficient Envs for the promotion of both cortical F-actin reorganization and capping, with neither signal stabilizing acetylated α-tubulin. The gene discussed is ERVW-1; the disease is infection.