In the present study, the expression of PI3K, p-AKT1, p-Erk1/2 and Ras-GTP was significantly increased by rhGDF15 treatment or GDF15 overexpression but was decreased by GDF15 knock down, which indicates that GDF15 promotes cervical cancer cell proliferation through the PI3K/AKT and MAPK/ERK signaling pathways. This evidence concerns the gene MAPK3 and cervical cancer.