To validate the correlation between the expression of GDF15 and PI3K/AKT and MAPK/ERK signaling-related proteins in cervical cancer specimens, the expression of GDF15, p-AKT, p-Erk1/2, C-myc and FOXO1 was detected by IHC (Fig. 7a). The gene discussed is FOXO1; the disease is cervical carcinoma.