TP53 and lung cancer: Meanwhile, we also did the correlation analysis between CXCL8 and other known tumor suppressor genes, such as p53 and CDKN1B, and there were no significant negative relationship between CXCL8 and those genes in both lung cancer patients (p = 0.480, p = 0.264) and lung cancer cell lines (p = 0.063, p = 0.426) (Fig. 4e–h).