CXCL8 and metastatic malignant neoplasm in the lymph nodes: As shown in Fig. 3b, four factors, including lymph node metastasis (hazard rate (HR) = 4.037; 95% CI 1.706–9.551; p = 0.001), tumor size (HR = 2.315; 95% CI 1.072–4.996; p = 0.033), TNM stage (HR = 5.965; 95% CI 2.588–13.753; p = 0.000), and CXCL8 expression (HR = 2.210; 95% CI 1.059–4.615; p = 0.035), were obviously associated with the clinical outcomes of ADC patients, while other parameters were not the direct prognostic factors.