GAD2 and epilepsy: A possible role of GAD65 in the pathogenesis of epilepsy is supported by reports of abnormalities of GABAergic neurotransmission in animal models of epilepsy [11], epileptic seizures in GAD65-knock-out mice [12], reduction of GABA levels in CSF and brain tissue of epileptic patients [13], and epileptic syndromes associated with GAD65Ab [14].