MRAK-159688, which was another up-regulated lncRNA identified in our study, is associated with the Fos gene and was named the Fos downstream transcript (FosDT) in a report from Mehta et al. [32] Mehta et al. reported that, in an ischemia/reperfusion model, FosDT interacts with the chromatin-modifying proteins Sin3a and co-repressor of the transcription factor REST (coREST) and subsequently represses REST-downstream genes. The gene discussed is REST; the disease is ischemia.