APOC1 and early-onset autosomal dominant Alzheimer disease: A 4-bp CGTT deletion (H1)/insertion (H2) polymorphism (rs11568822) at the − 317 site in the apoC1 promoter region has been reported to affect apoC1 gene expression [18, 19] and is related to the risks of late-onset Alzheimer’s disease [20] and type III hyperlipoproteinemia [21].