APOB and acne: However, the apoC1 rs4420638A → G variation may potentially be linked to elevated serum LH levels, a relatively high ratio of LH to FSH, and an adverse lipid metabolic profile; and the -317 H1H1 genotype is associated with increased the ratio of apoB-PAF-AH to H-PAF-AH activity and the acne grade score in the patients with PCOS.