This analysis revealed that refitting with human mutational signatures 1 and 5, both of which are “clock-like” age-associated signatures, which are almost universally active in human cancer and normal cells and are not indicative of exogenous mutational exposures (Alexandrov et al., 2013, Alexandrov et al., 2015a, Blokzijl et al., 2016, Ju et al., 2017, Rahbari et al., 2016), adequately reconstructed the mutational spectra observed in both DFT1 and DFT2 (cosine similarity 0.93 and 0.95, respectively) (Figure 2B; Table S2). The gene discussed is CLOCK; the disease is cancer.