MPDZ and cancer: Interestingly, both WWC3 and MPDZ are proposed to encode negative regulators of YAP1 and WWTR1/TAZ, core effectors of the Hippo signaling pathway, which has conserved roles in development, regeneration, and cancer (Han et al., 2017, Juan and Hong, 2016, Moroishi et al., 2015, Varelas et al., 2010, Zanconato et al., 2016).