Intriguingly a subset of tauopathies, including corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), fronto-temporal lobar degeneration with tau mutations (FTLD-tau) and myotonic dystrophy, are thought to be driven by changes in MAPT pre-mRNA alterative splicing [17]. The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.