PSMB3 and cancer: A series of up-regulated genes were enriched in the proteasome pathway, such as PSMA7, PSMB1 and PSMB3. The up-regulated genes SMAD3 was enriched in multiple pathways, such as cell cycle (hsa04110), pathways in cancer (hsa05200), and adherens junction (hsa04520) (Table 4).