TNFRSF1A and Nephropathy: In addition, in T2DM, the development of nephropathy is associated with the activation of CD8 + T cells and with the increase of interleukin-6 (IL-6), NLRP3 inflammasome, and TNFR1/2 (Tumor necrosis factor receptors 1 and 2) [34–37].