PARP1 and acute lymphoblastic leukemia: Pournazari et al.(34) have also shown a positive association between highPARP-1 expression and a complex karyotype in patientswith B-Cell Acute Lymphoblastic Leukemia (B-ALL).Other studies have shown the overexpression of PARP-1in 61% of adult ALL patients with B-ALL and in ALLchildren with poor response to treatment (35) suggestinga potential role for PARP-1 in ALL development.