MiR-126 exerts a variety of functions in cancer pathogenesis via suppression of expression of target geneincluding PI3K, KRAS, EGFL7, IRS-1 and VEGF. Our bioinformatic studies implementing DAVID database, showedthe involvement of miR-126 target genes in several signaling pathways including cancer pathogenesis, neurotrophinfunctions, Glioma formation, insulin function, focal adhesion production, chemokine synthesis and secretion andregulation of the actin cytoskeleton. The gene discussed is IRS1; the disease is central nervous system cancer.