Furthermore,miR-126 can affect many cellular mechanisms involvedin cancer pathogenesis via suppressing translation ofnumerous validated target gene such as PI3K, KRAS,EGFL7, CRK, ADAM9, HOXA9, IRS-1, SOX-2,SLC7A5 and VEGF in colorectal, gastric, oesophageal,oral, pancreatic, liver, thyroid, breast, cervical,ovarian, prostate, bladder, renal, and lung cancers aswell as melanoma, osteosarcoma and leukemia (16).We here used molecular signaling pathway enrichmentanalysis to determine possible associations betweenmiR-126 and IRS1 within neurotrophin pathway, forthe first time. This evidence concerns the gene IRS1 and melanoma.