IRS1 and glioma: MiR-126 exerts a variety of functions in cancer pathogenesis via suppression of expression of target geneincluding PI3K, KRAS, EGFL7, IRS-1 and VEGF. Our bioinformatic studies implementing DAVID database, showedthe involvement of miR-126 target genes in several signaling pathways including cancer pathogenesis, neurotrophinfunctions, Glioma formation, insulin function, focal adhesion production, chemokine synthesis and secretion andregulation of the actin cytoskeleton.