Otherwise, Anp32e promoted breast cancer cell proliferation and anti‐apoptosis ability by inhibiting phosphatase 2A, a tumor suppressor that represses the PI3K/AKT pathway, in a mouse model which indicated that ANP32E might promote cell cycle progression through multiple pathways (Nakahata et al., 2014; Switzer et al., 2011). This evidence concerns the gene AKT1 and breast cancer.