MiR‐145‐5p was suppressed by MALAT1 in DTX‐resistant PCa cells and might work as a tumour suppressor in PCa progression by targeting AKAP12. Briefly, a MALAT1/miR‐145‐5p/AKAP12 axis was demonstrated to regulate chemosensitivity of PCa cells to DTX. Here, MALAT1 is linked to posterior cortical atrophy.