FBXW7 and non-small cell lung carcinoma: To examine whether FBXW7 regulates epithelial–mesenchymal transition (EMT) in NSCLC cells, we knocked down FBXW7 using two different short hairpin RNA (shRNA) constructs (shFBXW7 56 and shFBXW7 58) into H1299 cells and HCC827 cells.