FBXW7 and lung adenocarcinoma: To assess the roles of FBXW7 in human lung cancer development, we first examined DNA copy number changes of FBXW7 in lung adenocarcinoma (AC) and squamous cell carcinoma (SCC) using The Cancer Genome Atlas data and found that deletion of FBXW7 was found in 71 of 230 (30.9%) ACs and 113 of 178 (63.5%) SCCs, while gain of FBXW7 was only found 19 (8.3%) ACs and 11 (6.2%) SCCs (Table S1).