This finding argues against an involvement of altered SUMO1 conjugation in the pathogenesis of AD, at least as it is apparent in the 5XFAD model, but does not exclude a link to SUMO2/3 conjugation in this model, as SUMO2/3‐conjugation is prone to react more robustly to stress (Bernstock et al., 2018; Liebelt & Vertegaal, 2016). The gene discussed is SUMO2; the disease is Alzheimer disease.