These dysfunctional processes are accelerated in major neurodegenerative diseases where misfolded amyloid beta, tau, huntingtin, ataxin, or α‐synuclein is thought to cause the synaptic stress and neuronal death observed in Alzheimer's disease (AD), Huntington's disease, ataxia, and Parkinson's disease (Krumova & Weishaupt, 2013). Here, MAPT is linked to Alzheimer disease.