However, IV tPA has varying efficacy depending on the stroke-affected artery (e.g., 31–44% recanalization of cases of a distal M2 branch of the middle cerebral artery (MCA), but only 4–8% recanalization of occlusions of the terminal internal carotid artery (ICA) [13, 14]). The gene discussed is PLAT; the disease is Stroke.