ADAM17 and Hyperkeratosis: Additionally, mice of both strains exhibited hyperkeratosis (H) and thickened epidermis (E), whereas enlargement of sebaceous glands (*) was observed only in Rhbdf2cub/cub mice, suggesting that deletion of ADAM17 partially reverses the loss‐of‐hair and sebaceous gland phenotypes of Rhbdf2cub/cub mice.