Recent genomics studies of patients with ACTH‐independent Cushing's syndrome revealed that ~ 40% of the adrenal adenomas from these patients carried a T617G mutation in the PRKACA gene, which encodes for the α‐isoform of the catalytic subunit of cAMP‐dependent protein kinase (PKACα) 2, 3, 4, 5. Here, POMC is linked to Cushing syndrome.