Recent genomics studies of patients with ACTH‐independent Cushing's syndrome revealed that ~ 40% of the adrenal adenomas from these patients carried a T617G mutation in the PRKACA gene, which encodes for the α‐isoform of the catalytic subunit of cAMP‐dependent protein kinase (PKACα) 2, 3, 4, 5. This evidence concerns the gene PRKACA and adrenal cortex adenoma.