Recent genomics studies of patients with ACTH‐independent Cushing's syndrome revealed that ~ 40% of the adrenal adenomas from these patients carried a T617G mutation in the PRKACA gene, which encodes for the α‐isoform of the catalytic subunit of cAMP‐dependent protein kinase (PKACα) 2, 3, 4, 5. The gene discussed is PRKACA; the disease is Cushing syndrome.