Single missense mutation in Muc2 gene leads to misfolding of the major secreted intestinal mucin Muc2, resulting in a strong UPR response and subsequent development of spontaneous colitis characterised by activation of both innate and adaptive immunities with an IL‐23/TH17 phenotype.28, 29 Immune‐regulated alterations in mucin glycosylation following Trichuris muris infection contribute to clearance of parasitic infection.30 The gene discussed is MUC2; the disease is colitis.