Resistance to rociletinib and osimertinib, whilst not yet fully understood, is thought to recurrently involve MET, EGFR, PIK3CA, ERRB2, KRAS, and RB1 pathways, as well as the possibility of neuroendocrine transformation to SCLC [27, 86, 108]. Here, EGFR is linked to small cell lung carcinoma.