The echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion gene was identified for the first time in 2007 in a 62 year-old male patient with lung adenocarcinoma, ALK-rearrangements serve as a key oncogenic driver that occur in 3%–7% of patients with NSCLC [1, 2]. The gene discussed is EML4; the disease is non-small cell lung carcinoma.