FUCA1 and cancer: This work was partially supported by Progetto PON01_02782 “Novel nanotech strategies for development of drugs and diagnostics for targeting of circulating cancer cells” of the MIUR, Italy to the Istituto Superiore di Oncologia (ISO) and by the project “Role of α-L-fucosidase -1 in thyroid and breast cancer” awarded by the Istituto Banco di Napoli-Fondazione, Naples Italy.