On the basis of the effects of CPTH2 in lowering p300 and H3AcK18 and the vast literature on the relevance of this histone mark as prognosticator in cancer patients, we wanted to extend the analysis of histone H3 acetylation at K18 and K14 along with p300 in 70 cases of ccRCC tumor patients (listed in Table 1). The gene discussed is EP300; the disease is nonpapillary renal cell carcinoma.