As expected, expression of H3AcK18 and H3AcK14 was limited to the cell nucleus of both clear renal cell carcinoma and epithelial cells of normal kidney (podocytes and epithelial cells of the proximal and distal tubules), whereas KAT3B-p300 antibody stained both the nucleus and the cytoplasm in 42/70 ccRCC cases and 67/69 epithelial cell of the peritumoral normal kidneys. The gene discussed is EP300; the disease is nonpapillary renal cell carcinoma.