INS and diabetes mellitus: In these studies, insulin was administered as a transient intravenous insulin infusion, which lowered the mean glucose level and reduced insulin requirements by 40 %.18,19 A sequential utilisation of intravenous insulin infusion for 4 weeks followed by CSII for 1 year was undertaken by Pouwels et al. in eight obese T2D patients with diabetes with poorly controlled diabetes despite high insulin requirement (~2 U/kg/day).