Before OPT2MISE, few randomised controlled studies had compared the effectiveness of CSII versus MDI and had actually drawn contrasting conclusions (see Table 1).8–11 Two parallel-group studies were conducted in type 2 obese patients with diabetes treated with insulin therapy including at least one daily injection, with a mean HbA1c between 8 % and 8.4 %. Here, INS is linked to diabetes mellitus.