GLP1R and type 2 diabetes mellitus: In a direct comparison, the add -on of dulaglutide to patients failing on metformin was non-inferior compared with the addition of insulin glargine at the 0.75 mg dose and superior at the 1.5 mg dose.4 A direct head-to-head study comparing liraglutide with dulaglutide (in their respective maximal doses approved for type 2 diabetes therapy) showed non-inferiority for dulaglutide regarding the reduction of HbA1c and body weight.17,24 The incidence of hypoglycaemic episodes and the adverse event profile was similar to other GLP-1 RAs.