Among the 11 isoforms of HDACs, HDAC6 activation has been reported to be involved in the pathogenesis of rhabdomyolysis-induced AKI for the contribution to renal tubular cell apoptosis, inflammatory response, macrophage infiltration and oxidative stress (Liu and Zhuang, 2015; Shi et al., 2017). The gene discussed is HDAC6; the disease is acute kidney injury.