Similarly, overexpression of a human VPS35 D620N variant in Drosophila also leads to PD-like phenotypes, including loss of tyrosine-hydroxylase (TH)-positive DA neurons, locomotor dysfunction, reduced lifespan and increased sensitivity to rotenone (a PD-associated environmental toxin) (Wang H.S. et al., 2014). The gene discussed is VPS35; the disease is Parkinson disease.