SNX27 serves as an early endosome-associated cargo adaptor for endosomal sorting of various transmembrane proteins (Lauffer et al., 2010; Ghai et al., 2013), including β2-adrenergic receptor (Temkin et al., 2011), glucose transporter GLUT1 (Kvainickas et al., 2017) and AD-related proteins, such γ-secretase and APP (Wang X. et al., 2014; Huang et al., 2016). The gene discussed is APP; the disease is Alzheimer disease.