CASR and autosomal dominant polycystic kidney disease: In contrast, another study evaluating the effect of CaSR activation with NPS-R568 in animal models orthologous to human ADPKD and/or ARPKD (Autosomal Recessive Polycystic Kidney Disease), reported no detectable effect on cystogenesis but possible beneficial effect on interstitial fibrosis15,16,62,63.