Inhibition of Cxcr2 by SB25002 was associated with reduction of Treg cells and MDSC, and an increasing the percentage of CD8+ T cells, macrophages, NK cells and dendritic cells, which was consistent with previous studies demonstrating the ability of SB225002 to suppress MDSC infiltration in breast tumor xenografts30 and prostate tumors31, as well as metastasis via S100A8/A930. This evidence concerns the gene S100A8 and breast neoplasm.