As a result, we identified an aggregation of rare coding alleles in CETP (p = 1.39 × 10−32), SH2B1 (p = 1.47 × 10−6), and ZFP2 (p = 3.08 × 10−6), that significantly associated with MetS, using Bonferonni correction (P = 4.11 × 10−6 (0.05/12153), Supplementary Table S4). The gene discussed is ZFP2; the disease is metabolic syndrome.