CETP and metabolic syndrome: Therefore, we assessed each of the four protein-changing missense mutationsD459G, G331S, A390P, and E314K, for their effects on CETP, for MetS, By single variant association study, we successfully identified significant association of less common variants in CETP, with regard to MetS, namelyrs2303790 (MAF = 0.04, encoding D459G; from MulA, P = 1.73 × 10−31; from LR, OR = 0.71, p = 9.67 × 10−4), in the discovery stage (Table 3, Supplementary Table S5).