HECTD4 and metabolic syndrome: Data from the discovery stage also confirmed the previously identified MetS-related variants rs12229654 (P = 9.05 × 10−19), in LOC101929011, rs11066280 (P = 5.91 × 10−27), in HECTD4, and rs780092 (P = 5.88 × 10−14), in GCKR, based on analysis by both LR and MulA (Supplementary Table S1).