Previous genome-wide association studies (GWAS)5–9 have suggested susceptibility to ALL is polygenic, identifying single-nucleotide polymorphisms (SNPs) in eight loci influencing ALL risk at 7p12.2 (IKZF1), 9p21.3 (CDKN2A), 10p12.2 (PIP4K2A), 10q26.13 (LHPP), 12q23.1 (ELK3), 10p14 (GATA3), 10q21.2 (ARID5B), and 14q11.2 (CEBPE). Here, IKZF1 is linked to acute lymphoblastic leukemia.