Acknowledging limitations that these cell types may not fully reflect ALL biology, the regions containing rs28665337 and rs17481869 show significant chromatin looping interactions with the promotor regions of MYC in ES cells and GTDC1 in GM12878, respectively (Fit-Hi-C test18, Supplementary Figs. 7, 8). This evidence concerns the gene MYC and acute lymphoblastic leukemia.