In addition to previously reported loci we identified three risk loci for BCP-ALL at 8q24.21 (rs28665337, hg19 chr8:g.130194104) and 5q21.3 (rs7449087, hg19 chr5:g.107928071), and for ETV6-RUNX1-positive ALL at 2q22.3 (rs17481869, hg19 chr2:g.146124454) (Fig. 2, Tables 1 and 2, Supplementary Table 3). The gene discussed is RUNX1; the disease is acute lymphoblastic leukemia.