Those with dementia had significantly higher levels of NF-L (median 63.76 ng/L vs. 19.96 ng/L; Mann-Whitney U test p < 0.001), and a logistic regression model adjusting for age, sex, and APOE4 status revealed that NF-L levels remained predictive of dementia status (p = 0.022). This evidence concerns the gene NEFL and dementia.