KCNMA1 and cocaine dependence: Interestingly, a drug repositioning study that integrated disease and drug expression profiles identified KCNMA1 as a potential molecular target for lobeline: a natural alkaloid that has been used as a smoking cessation aid [43] as well as for amphetamine and cocaine addictions [44] KCNMA1 is a target for the FDA approved drug, chlorzoxazone, which is a centrally acting muscle relaxant.