PTK2 and lung cancer: 5e and f, the diminution of activated ERK (p-ERK) was notified in detached H460 cells incubated with avicequinone B (1–4 μM). Meanwhile there were no significant alteration of AKT and p-AKT expression in avicequinone B treated-H460 cells compared with non-treated control. This inhibitory effect on integrin/FAK/Src survival pathway corresponded with sensitization to anoikis (Fig. 3) and low colony formation (Fig. 4) in human lung cancer cells exposed with avicequinone B.