Anoikis is apoptosis cell death induced by detachment condition, the alteration of apoptosis-regulating proteins including Bcl-2, Mcl-1, Bax and caveloin-1 was examined in H460 cells treated with avicequinone B. In order to escape from anoikis, human lung cancer H460 cells can sustain the level of anti-apoptosis proteins during non-adherent circumstance [29]. This evidence concerns the gene BCL2 and lung cancer.