In conclusion, our study provided the evidence indicating that avicequinone B suppressed survival and induced anoikis in human lung cancer cells under detachment condition through inhibition on integrin/FAK/Src signaling and down-regulation of anti-apoptosis protein including cavelolin-1, Mcl-1 and Bcl-2 (Fig. 7). The gene discussed is BCL2; the disease is lung carcinoma.