In more detail, they observed that differences in bulk gene expression profiles between oligodendrogliomas and astrocytomas can be primarily explained by the impact of characteristic tumor class-specific mutations (oligodendrogliomas: 1p/19q co-deletion, CIC mutations; astrocytomas: TP53 mutations) and differences in the composition of the tumor microenvironment, but not by distinct expression programs of glial lineages of malignant cells. The gene discussed is TP53; the disease is astrocytoma (excluding glioblastoma).