Similarly, Som et al. reported thatproanthocyanidins protect skin from UVB-induced damage by inhibitingMAPK/NF-κB signaling pathways [57].Moreover, findings from Sun [58] and Miaoet al. [14]show elevated Nrf2 and HO-1 protein expression in the presence of proanthocyanidins.HO-1 in particular reportedly blocks the STAT3 signaling pathway [53] and further mitigates oxidative damagein diabetes, following induction by zearalenone. Here, HMOX1 is linked to diabetes mellitus.