TP53 and carcinoma of esophagus: In summary, we present a detailed characterisation of the cellular response to [Ru(phen)2(tpphz)]2+ (Ru1) in p53-deficient oesophageal cancer cells, finding this ruthenium(ii) metallo-intercalator induces a potent replication block accompanied by replication stress and DSB damage repair pathway activation, without triggering apoptosis.