GRM4 and Parkinson disease: To demonstrate an application, the current aminocarbonylation method was applied for the synthesis of a bioactive molecule, 5, which is a potent allosteric modulator of metabotropic glutamate receptor 4 (mGluR4) for the potential treatment of Parkinson’s disease (Fig. 5).13 Indeed, our method allowed the synthesis of 5 in 63% yield.