MTOR and atherosclerosis: 36,37 Fluorescently tagged ASOs were used to monitor the endosome rupture and cytosolic H2O2-triggered release. Targeted delivery and “on-demand” release of ASOs to high-fat diet-fed ApoE–/– mice efficiently depleted mTOR expression and rescued the impaired autophagy, which led to a dramatic reduction in foam cell formation and atherosclerotic lesion progression (Scheme 1B). These results suggested that the S2P–CeO2–ASOs nanoplatform can be a potential new therapeutic option for atherosclerosis.