Moreover, the frequencies of these CD27+IgD+ B cells were inversely correlated with RA patient disease activities (DAS28) and the clinical manifestations, including the tender joint counts (TJC), swollen joint counts (SJC), and the anti-cyclic citrullinated protein (anti-CCP) antibodies, but not the ages and disease duration (Figures 2B–G; Table 2). The gene discussed is CD27; the disease is rheumatoid arthritis.