INS and Hyperglycemia: IRS2−/− mice had higher non-fasting levels of plasma insulin (9 ± 1 vs. 20 ± 2 μU/ml, p < 0.01) and exhibited fasting hyperglycemia (5.3 ± 0.57 vs. 12.6 ± 2.7 mMol/l, p < 0.05) than IRS2+/+.