XDH and hyperuricemia: Al-Azzawie and Abd (2015) showed that the Z. officinale extract had the highest xanthine oxidase inhibition in vitro (87.97%) at 250 mg/mL; at both doses (100 and 250 mg/kg), ginger extract significantly reduced mean serum uric acid levels and inhibited xanthine oxidase activity in hyperuricemia rats.