HNRNPA2B1 and amyotrophic lateral sclerosis: Their mutations have been found in the familial multisystem proteinopathy and ALS, two devastating diseases resulting from the progressive degeneration of the neural system; and expression of the mutant hnRNPA2B1 and hnRNPA1 in transgenic Drosophila recapitulates the phenotype and pathology to some extent demonstrated in human (Kim et al., 2013).