LSM2 and Alzheimer disease: It is known that some neurodegenerative disorders are caused by the aberrancy of RNA processing proteins (Neumann et al., 2006; Sreedharan et al., 2008; Mackenzie et al., 2010), but whether the pathogenesis of AD possibly involves a similar mechanism had remained unclear, until we have found the U1 small nuclear ribonucleoprotein (snRNP) complex pathology and the RNA splicing deficiency in AD patents (Bai et al., 2013).