cDC1 are specialized cross-presenting cells and are highly immunogenic within the tumor environment.5, 8 We have previously exploited the temporal depletion of CD11c+ cells from CD11c.DTR mice to demonstrate the potency of repopulating cDCs in LNs to cross-present lentiviral antigen in a vaccination immunotherapy model.22 This evidence concerns the gene MPPE1 and neoplasm.