As an initial approach to dissect the role of tumor-resident CD11c+ populations in the activation of TCR gene-modified T cells, we analyzed the inducible depletion of cDCs, and other CD11c+ cells, 48 hr after injection of diphtheria toxin (DT) into CD11c.diphtheria toxin receptor (DTR) mice bearing subcutaneous B16 tumors. This evidence concerns the gene ITGAX and neoplasm.