MPPE1 and neoplasm: These lineages and their functions are conserved in humans.2, 3, 4 Of these, cDC1 are highly efficient at cross-presenting antigens to cytotoxic T cells and are the major stimulatory cDC population within tumors, both for the generation of anti-tumor immunity in draining lymph nodes (LNs) and upon direct interaction with effector T cells within the tumor microenvironment.5, 6, 7, 8 Furthermore, cDC1 are critical for therapeutic responses to checkpoint blockade,9, 10, 11 but their possible role in modifying the function of engineered T cells has not been as extensively studied.