In hematologic malignancies, gain of 1q has been associated with overexpression of the CKS1B gene in 1q21 in multiple myeloma [17, 18] and with upregulation of B4GALT3 (1q23), DAP3 (1q22), RGS16 (1q25), TMEM183A (1q32), and UCK2 (1q24) in a few dup(1q)-positive HeH cases[21]. This evidence concerns the gene CKS1B and plasma cell myeloma.