However, there are several examples of gains associated with gene mutations on the chromosomes involved, such as KIT mutations and trisomy 4 and internal tandem duplications of KMT2A and trisomy 11 in acute myeloid leukemia, MET mutations and trisomy 7 in hereditary papillary renal carcinomas, and JAK2 mutations and trisomy 9 in polycythemia vera[46–49]. This evidence concerns the gene JAK2 and acute myeloid leukemia.