NF2-null mouse schwannoma cells (SC4) or immortalized human Schwann cells that stably suppress neurofibromin 2 expression (hSCλ-shNF2), or immortalized human embryonic kidney cells (293 T), were transfected with expression plasmids for wild type and mutant neurofibromin 2 and cell numbers were counted up to 72 h. This evidence concerns the gene NF2 and schwannoma.