Thus, chemotherapies to slow or eliminate tumor formation are urgently needed, especially since NF2 mutations that result in inactivation of its gene product, neurofibromin 2 (also known as schwannomin or merlin for moesin-ezrin-radixin-like protein), are also found in spontaneous meningiomas and schwannomas and several other types of cancers, such as breast, colorectal, clear cell renal cell carcinoma, hepatic, glioma multiforme, mesothelioma, and prostate. The gene discussed is NF2; the disease is mesothelioma.