The median duration of response (DR) was 3.8 months (95% CI,; 1.9–5.6 m; which varied among pathological subtypes: 3.1 m (95% CI; 2.7–4.1 m) for osteosarcoma, 2.0 m (95% CI; 1.3–2.7 m) for Ewing’s sarcoma, 5.2 m (95% CI; 0.9–9.5 m) for synovial sarcoma, 8.8 m (95% CI; 4.3–11.5 m) for MPNST, and 5.6 m (95% CI, 1.3–9.8 m) for UPS (Table 3). This evidence concerns the gene HMBS and Ewing sarcoma.