Ultimately, detailed studies using radiotelemetry in concert with echocardiography are required to fully evaluate temporal changes in hemodynamic response to AngII, and the mechanism of decompensation in the GPR37L1KO/KO male mice, and whether GPR37L1 conveys cardioprotection in other cardiovascular disease models (i.e., thoracic aortic constriction, myocardial infarction). Here, AGT is linked to cardiovascular disorder.